IEEE DTPI 2025 will present the cutting-edge research and technical progress of the rapidly evolving field of digital twinning. The 2025 Conference will be held in-person in Atlanta, GA near the campus of Georgia Tech. The conference aims to brings together scholars and industrial practitioners to share scientific and technological advances as well as to gain a deeper understanding of generating digital twins and deriving parallel intelligence. DTPI’s particular topics also include standards, theory, practice, and various vertical applications of DTPI, including smart cities, transportation, energy, robotics, manufacturing, healthcare, spectrum management, etc.